Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. BackgroundThe constant resistance ratio (cRR) is a novel nonhyperemic pressure ratio based on piezoresistive pressure microcatheter (PMC) measurements.
With repeated measurements in randomized order of PMC and pressure wire techniques, this study aimed primarily to validate the diagnostic performance of cRR compared with fractional flow reserve (FFR) in coronary lesions of 30% to 90% diameter stenosis.MethodsSUPREME II (Sensor‐Equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements) was a multicenter, prospective study that included 466 patients (483 vessels) from 11 centers. All target vessels were assessed using both pressure wire and PMC separately in randomized order under resting and hyperemic conditions.
The primary end point was the diagnostic accuracy of the cRR using a PMC‐based FFR of ≤0.80 as the reference standard.
Journal of the American Heart Association published a clinical update in Cardiology on 13 Mar 2026.
The item focuses on Clinical Validation of a Novel Pressure Microcatheter‐Based Nonhyperemic Pressure Ratio (SUPREME II Study).
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