In the final analysis of the randomized, phase 3 RATIONALE-312 trial (data cutoff: April 19, 2023), patients with extensive-stage SCLC (ES-SCLC) who received first-line tislelizumab plus chemotherapy experienced significant improvements in overall survival (OS; HR = 0.75 [95% CI: 0.61–0.93]; one-sided p = 0.004) and tolerable toxicity compared with placebo plus chemotherapy. We report long-term follow-up (data cutoff: December 29, 2023) data.
Journal of Thoracic Oncology (JTO) published a clinical update in Oncology on 05 Mar 2026.
The item focuses on First-Line Tislelizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Extensive-Stage SCLC: A Long-Term Survival and Programmed Death-Ligand 1 Subgroup Analysis From the Randomized, Phase 3 RATIONALE-312 Trial.
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