While IgA1 is well established as pathogenic in IgA nephropathy (IgAN), IgA2’s role remains controversial. The most notable difference between IgA1 and IgA2 lies in the hinge region: IgA2 lacks a 13–amino acid segment unique in IgA1, which contains nine serine and threonine residues that can be O-glycosylated. Here, we investigated the role of IgA2 in the development of IgAN.
Kidney International published a clinical update in Research Highlights on 13 Mar 2026.
The item focuses on Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy.
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