A middle-aged man presented with >10 years of intermittent dark-colored urine. Laboratory tests showed hemoglobin, 112 g/l; serum creatinine, 75.7 μmol/l; and elevated lactate dehydrogenase, 26.88 μkat/l.
Urinalysis revealed hematuria (25 red blood cells/high-power field), 1+ protein, positive urobilinogen, and protein, 0.5 g/d. Kidney biopsy showed granular degeneration of renal tubular epithelial cells and brown pigment deposits in the cytoplasm (Supplementary Figure S1A).
Prussian blue staining confirmed hemosiderin in renal tubular epithelial cells (Figure 1a).
Kidney International published a clinical update in Research Highlights on 13 Mar 2026.
The item focuses on Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria.
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