A 33-year-old man presented for evaluation of markedly enlarged kidneys with multiple large cysts consistent with autosomal dominant polycystic kidney disease, as demonstrated on abdominal magnetic resonance imaging (height-adjusted total kidney volume 577.2 ml/m) (Figure 1a). Five years prior, he was diagnosed with autosomal dominant polycystic kidney disease on the basis of family history and the presence of male infertility and cystic renal changes. Subsequent evaluation identified multiple seminal vesicle cysts (Figure 1b).
Kidney International published a clinical update in Research Highlights on 13 Mar 2026.
The item focuses on Dual-hit cystic kidneys: ADPKD with de novo HNF1B deletion.
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