Renal damage in type 2 diabetes exemplifies a complex, multisystemic disorder with substantial heterogeneity in clinical trajectory, histopathology, and molecular drivers. Traditional clinical markers, albuminuria and glomerular filtration rate, fail to capture this diversity because many patients follow atypical trajectories such as nonalbuminuric progression, rapid estimated glomerular filtration rate decline, or regression of albuminuria. Deep endotyping approaches integrating clinical dynamics, renal histopathology, and multi-omics profiling can define biologically distinct endotypes.
Kidney International published a clinical update in Research Highlights on 27 Feb 2026.
The item focuses on Deep endotyping of renal damage in type 2 diabetes: ex uno, plures.
Review the original article for the full source wording and details.