Kidney fibrosis is the underlying pathological process of chronic kidney disease, a major global medical challenge. In most diseases, fibrosis-initiating injury affects epithelial cells.
However, the fibrosis-executing cells are interstitial mesenchymal cells, particularly fibroblasts, expressing the platelet-derived growth factor (PDGF) receptor β (PDGFR-β). Here, we analyzed the cell-specific functional relevance of the PDGFR-β ligand, PDGF-B, in the cellular crosstalk in kidney fibrosis.
Kidney International published a clinical update in Research Highlights on 27 Feb 2026.
The item focuses on Tubular cell-specific platelet-derived growth factor-B drives formation of fibrogenic niches in kidney fibrosis.
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