Membranous nephropathy (MN) in very elderly patients frequently remains antigen-negative after routine testing, limiting diagnostic precision. Recently, serine protease high temperature requirement protein A1 (HTRA1) has been identified as a novel MN autoantigen. Here, we focused on patients 80 years and older with MN and sought to systematically evaluate this association.
Kidney International published a clinical update in Research Highlights on 27 Mar 2026. The item focuses on Serine protease HTRA1 is a common autoantigen in membranous nephropathy in patients of 80 years and older. Open the detail page to review the full original feed content.