Abnormal differentiation of T helper 17 (Th17) cells is an important mechanism underlying lupus nephritis (LN) pathogenesis. However, its driving mechanism remains unclear.
Modification of m6A, the most dominant RNA modification, is a novel mechanism for regulating cell phenotypes and functions, with methyltransferase-like 3 (METTL3) being an important methyltransferase. Nonetheless, whether m6A modification participates in the regulation of Th17 cell differentiation in patients with LN has not been reported.
Kidney International published a clinical update in Research Highlights on 19 Feb 2026.
The item focuses on METTL3-targeted intervention on nuclear factors RORA/RORγt suppressing pathogenic T helper 17 cell differentiation and restores kidney damage in lupus nephritis.
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