Membranous nephropathy (MN) is a rare autoimmune kidney disease characterized by the deposition of immune complexes (ICs) in the subepithelial space between podocytes and the glomerular basement membrane1. Deposition of ICs is associated with effacement of podocyte foot processes, leading to heavy proteinuria and kidney failure. Subepithelial ICs represent a long-standing hallmark of MN described more than 60 years ago, yet their appearance, clearance, and functional significance remain debated.
Kidney International published a clinical update in Research Highlights on 26 Mar 2026.
The item focuses on Autoimmunoglobulin-triggered extracellular vesicles as New Players in Membranous Nephropathy: Friends or Foes?.
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