An adult human kidney is composed of >30 different types of cells. Its full functionality depends not only on the diversity of these cells, but also on their precise spatial organization.
On average, each human kidney contains approximately 1 million nephrons, all of which drain into a single ureteral outlet. This remarkable spatial architecture is orchestrated by reciprocal interaction between 2 key progenitor populations: nephron progenitor cell (NPC) and ureteric progenitor cell (UPC).
During kidney morphogenesis, these progenitors interact in a highly concerted manner, ensuring that multiple nephrons connect seamlessly to a single collecting duct (CD) tree.
Kidney International published a clinical update in Research Highlights on 12 Feb 2026.
The item focuses on Multilineage assembly brings spatial order to human kidney organoids.
Review the original article for the full source wording and details.