Fabry disease (FD) is a systemic disorder with manifestations of heart, vascular, and kidney disease. Identical genetic variants in the α-galactosidase A (GLA) gene exhibit variable clinical phenotypes consistent with the existence of disease modifiers. Prior work in the Gla null mouse identified the vascular endothelium as a primary site for dysfunction associated with FD vasculopathy.
Kidney International published a clinical update in Research Highlights on 22 Jan 2026.
The item focuses on Heat shock protein 70s are modifiers of endothelial function in Fabry disease.
Review the original article for the full source wording and details.