Chronic kidney disease of undetermined etiology (CKDu) is a major cause of mortality that affects communities, health systems, and national economies. Despite 2 decades of descriptive and analytical research, the causes of CKDu epidemics remain unclear.
In February 2025, at the World Congress of Nephrology, the International Society of Nephrology’s International Consortium of CKDu Collaborators met to discuss the obstacles to determining the cause(s) of the epidemics. Several key themes were identified: First, differences in CKDu burden between regions are poorly described, and this is complicated by inconsistent terminology.
Kidney International published a clinical update in Research Highlights on 20 Jan 2026.
The item focuses on Taking the “unknown” out of CKDu—optimizing approaches to uncover the cause(s) of epidemic-level kidney disease in low- and middle-income settings: a report from the ISN’s International Consortium of CKDu Collaborators (ISN i3C).
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