Membranoproliferative glomerulonephritis (MPGN) has undergone a change in classification that is focused on the etiology of MPGN. Thus, MPGN is classified into immune-complex (IC)-mediated MPGN and complement-mediated MPGN (C3 glomerulopathy) based on immunofluorescence microscopy (IF) studies that show positive staining for immunoglobulins and/or C3.
IC-MPGN typically results from an infection or an autoimmune disease. Deposition of monotypic/monoclonal Ig also results in an MPGN.
On the other hand, MPGN with bright C3 and minimal/no immunoglobulin is classified as C3 glomerulopathy.
Kidney International published a clinical update in Research Highlights on 25 Mar 2026.
The item focuses on Finding the etiology of MPGN.
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