We integrated large-scale epidemiological and genomic data from patients with esophageal adenocarcinoma to compare cancers with and without Barrett’s esophagus (BE). We found shared risk factors, molecular features, evolutionary trajectories and BE lineage markers in both cancer phenotypes.
Our findings support a single intestinal metaplasia-mediated pathway and have direct implications for early detection and prevention strategies. Access to this article via Institution of Civil Engineers Library is not available.
Kolb, J. M.
et al. Prognostic impact of the presence of Barrett’s esophagus and intestinal metaplasia on esophageal adenocarcinoma survival.
Foregut 2 , 356–364 (2021). This study establishes that many patients with EAC have no identifiable BE and that distinct prognostic phenotypes exist based on the presence or absence of BE.
Peters, C. J.
et al. A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium.
Nat. Med.
30 , 14–16 (2023). This article describes the multi-center OCCAMS consortium that enabled the collection of the massive, prospective cohort of 3,100 patients with EAC analyzed in this investigation.
Lagergren, J. et al.
Nature Medicine published a clinical update in Research Highlights on 23 Apr 2026.
The item focuses on Intestinal metaplasia is the only precursor to esophageal adenocarcinoma.
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