Regulatory T cells are responsible for suppressing inflammation, yet they fail to do so in rheumatoid arthritis. We show that signals in the local tissue environment can drive these cells into either protective or dysfunctional states.
Access to this article via Institution of Civil Engineers Library is not available. Shevach, E.
M. Regulatory T cells in autoimmmunity.
Annu. Rev.
Immunol. 18 , 423–449 (2000).
This review outlines the fundamental role of T reg cells in maintaining immune tolerance and preventing autoimmunity. Nie, H.
et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.
Nat. Med.
19 , 322–328 (2013). This study demonstrates that T reg cells in RA exhibit impaired suppressive function owing to inflammatory signaling.
Panduro, M. & Benoist, C.
& Mathis, D. Tissue Tregs.
Annu. Rev.
Immunol. 34 , 609–633 (2016).
This review highlights the heterogeneity of T reg cells and their adaptation to different tissue environments. Firestein, G.
S. & McInnes, I.
B. Immunopathogenesis of rheumatoid arthritis.
Immunity 46 , 183–196 (2017).
Nature Immunology published a clinical update in Infectious Disease on 18 Jun 2026.
The item focuses on Why regulatory T cells fail to control inflammation in rheumatoid arthritis.
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