mRNA-based vaccines saved millions of lives during the COVID-19 pandemic, but they require frequent boosting and periodic updates to match emerging virus strains. We demonstrate that fungal glycans can function as adjuvants for mRNA-based vaccines, expanding the durability and breath of protection against several virus strains.
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This article reports that both the lipid shell and the mRNA within mRNA-based vaccines exert immunostimulatory functions necessary for the activation of T follicular helper cells and antibody production. Brubaker, S.
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Nature Immunology published a clinical update in Infectious Disease on 25 May 2026.
The item focuses on Fungal glycans boost mRNA-based vaccines.
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