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CD4+ T Cells Expressing EOMES and Granzyme K Regulate T Cell–Mediated Colitis

A distinct CD4+ T cell subset expressing EOMES and granzyme K is identified in mouse and human colitis models, and is regulated by transcription factor EOMES.

GIST

Nature Immunology, Published online: 02 April 2026; doi:10.1038/s41590-026-02479-6 Xie et al. identify a distinct subset of CD4+ helper T cells expressing EOMES and granzyme K in both mice and human models of colitis.

Clinical Editorial

Nature Immunology published a clinical update in Infectious Disease on 02 Apr 2026. The item focuses on A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation. Review the original article for the full source wording and details.

Original source: https://www.nature.com/articles/s41590-026-02479-6