Mapping where mouse models match — and miss — human tumor immunity

A systematic comparison of the tumor microenvironment (TME) in mouse models and humans reveals that widely used models capture only a limited subset of the cellular diversity and cell type-specific gene expression observed in human TMEs. We present a resource that defines the conserved and divergent features, including shared gene programs, across mouse and human TMEs to guide model selection and improve the translational reliability of immunotherapy studies.

Access to this article via Institution of Civil Engineers Library is not available. Thorsson, V.

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Conserved pan-cancer microenvironment subtypes predict response to immunotherapy. Cancer Cell 39 , 845–865.e7 (2021).

This paper reports four immune and fibrotic TME subtypes conserved in a broad array of cancers. Combes, A.

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Discovering dominant tumor immune archetypes in a pan-cancer census. Cell 185 , 184–203.e19 (2022).

This paper identifies 12 unique tumor archetypes spanning cancer types. Gavish, A.

et al.