Nature Reviews Neurology, Published online: 14 April 2026; doi:10.1038/s41582-026-01210-1 Granulovacuolar degeneration bodies (GVBs) are lysosomal structures that appear in some neurons in response to pathological tau accumulation in Alzheimer disease. New research published in Science Advances indicates that these GVBs make neurons resilient to tau-induced neurodegeneration.
Nature Reviews Neurology published a clinical update in Neurology on 14 Apr 2026. The item focuses on Granulovacuolar degeneration bodies protect neurons from tau pathology. Open the detail page to review the full original feed content.