Podocyte injury and mesangial activation are hallmarks of a wide variety of glomerular diseases. Although podocyte damage is thought to be an early event that causes subsequent mesangial activation, the mechanism connecting these two events remains poorly understood. Since the protein fibrillin-1 (FBN1) may be involved in glomerular injury in several kidney diseases, we tested whether FBN1 expression in injured podocytes trigger mesangial cell activation and proliferation.
Podocyte injury and mesangial activation are hallmarks of a wide variety of glomerular diseases. Although podocyte damage is thought to be an early event that causes subsequent mesangial activation, the mechanism connecting these two events remains poorly understood. Since the protein fibrillin-1 (FBN1) may be involved in glomerular injury in several kidney diseases, we tested whether FBN1 expression in injured podocytes trigger mesangial cell activation and proliferation.