Fabry disease (FD) is a systemic disorder with manifestations of heart, vascular, and kidney disease. Identical genetic variants in the α-galactosidase A (GLA) gene exhibit variable clinical phenotypes consistent with the existence of disease modifiers. Prior work in the Gla null mouse identified the vascular endothelium as a primary site for dysfunction associated with FD vasculopathy.
Fabry disease (FD) is a systemic disorder with manifestations of heart, vascular, and kidney disease. Identical genetic variants in the α-galactosidase A (GLA) gene exhibit variable clinical phenotypes consistent with the existence of disease modifiers. Prior work in the Gla null mouse identified the vascular endothelium as a primary site for dysfunction associated with FD vasculopathy.