Abnormal differentiation of T helper 17 (Th17) cells is an important mechanism underlying lupus nephritis (LN) pathogenesis. However, its driving mechanism remains unclear. Modification of m6A, the most dominant RNA modification, is a novel mechanism for regulating cell phenotypes and functions, with methyltransferase-like 3 (METTL3) being an important methyltransferase. Nonetheless, whether m6A modification participates in the regulation of Th17 cell differentiation in patients with LN has not been reported.
Abnormal differentiation of T helper 17 (Th17) cells is an important mechanism underlying lupus nephritis (LN) pathogenesis. However, its driving mechanism remains unclear. Modification of m6A, the most dominant RNA modification, is a novel mechanism for regulating cell phenotypes and functions, with methyltransferase-like 3 (METTL3) being an important methyltransferase. Nonetheless, whether m6A modification participates in the regulation of Th17 cell differentiation in patients with LN has not been reported.