Mateus-Tique et al. demonstrate that targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity, leading to tumor clearance and improved survival in models of metastatic cancers.
Mateus-Tique et al. demonstrate that targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity, leading to tumor clearance and improved survival in models of metastatic cancers.