Wang et al. show that chemotherapy reprograms liver-resident Kupffer cells into LEPR+ tumor-infiltrating cells that clear immunogenic cell death signals via MerTK-dependent efferocytosis. Targeting chemotherapy-induced LEPR+ Kupffer cells restores tumor immunogenicity and overcomes chemoresistance in liver metastases.
Wang et al. show that chemotherapy reprograms liver-resident Kupffer cells into LEPR+ tumor-infiltrating cells that clear immunogenic cell death signals via MerTK-dependent efferocytosis. Targeting chemotherapy-induced LEPR+ Kupffer cells restores tumor immunogenicity and overcomes chemoresistance in liver metastases.