The bioRxiv record is for a preprint titled “A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition.” The title indicates the authors performed a functional genomics screen in the context of human B-cell differentiation and that their findings implicate convergent mechanisms related to inherited childhood leukemia predisposition. The provided SOURCE JINA BODY contains bibliographic and navigational material from the bioRxiv page but does not include the abstract text or the manuscript body that would describe experimental design, results, or conclusions.
The manuscript lists a multidisciplinary author team. Lead and contributing authors named in the provided content include Lara Wahlster, Anna-Lena Neehus, Andrew J. Lee, Soumyaa Mazumder, Pardiss Mehrzad, Susan Black, Luana Messa, Tanxin Liu, Charley Wang, Chen Weng, Alexis Caulier, Jensen Pak, Travis Fleming, Mateusz Antoszewski, Allison Zhang, Samuel A. Ha, Carmen Oleaga-Quintas, Adam J. de Smith, and Vijay G. Sankaran.
Affiliations reported in the source material include Boston Children’s Hospital, University of Southern California, the Whitehead Institute, and HHMI. Vijay G. Sankaran is listed as contact for correspondence (sankaran@broadinstitute.org).
This article is posted as a bioRxiv preprint and has not been peer reviewed, as noted on the bioRxiv page. The DOI given on the page is https://doi.org/10.64898/2026.08.06.743305. The bioRxiv record provides links to the abstract, article information and history, metrics, supplementary material, and a preview PDF of the full manuscript; however, those contents were not reproduced in the provided SOURCE JINA BODY.
From the content delivered in SOURCE JINA BODY, the following elements are present and can be reported without inference:
No experimental data, methods, gene lists, pathway analyses, sample sizes, cohorts, statistical outcomes, or specific conclusions are included in the provided body.
The SOURCE JINA BODY did not include the manuscript abstract or main text. As a result, the following critical elements are not reported in the provided source and cannot be invented or summarized beyond noting their absence:
Because these items are not present in the provided content, readers should consult the full preprint or supplementary materials for complete experimental and analytical detail.
The title suggests a study that connects molecular regulators of B-cell development to inherited risk for childhood leukemia. If confirmed by the manuscript, such findings could provide mechanistic links between germline variation and leukemogenesis during B-cell differentiation and may prioritize candidate genes or pathways for further study. However, the provided SOURCE JINA BODY does not include the necessary data to assess the strength of evidence, the scope of implicated mechanisms, or immediate clinical relevance.
Accordingly, any interpretation of implications for genetic screening, risk prediction, or therapeutic targeting would be speculative based on the title alone and is therefore not presented here.
The bioRxiv listing includes a preview PDF and links to supplementary material and article metrics. To review the experimental methods, datasets, gene or pathway results, and authors’ interpretations, consult the full preprint at the DOI provided (https://doi.org/10.64898/2026.08.06.743305) or the bioRxiv page for the article. For direct queries about the study, the correspondence email is sankaran@broadinstitute.org.
Note on preprint status
This work is a preprint and therefore should be interpreted as preliminary until peer review and formal publication. The SOURCE JINA BODY provided to this rewrite did not include the abstract or manuscript content; all statements above are restricted to metadata and the explicit information present on the bioRxiv page. Any detailed factual summary of methods, results, or conclusions requires inspection of the full preprint and supplementary files.