Collot et al. profile tumor and immune interactions in DMG. They identify DMG tumor cells that communicate with microglia through IGSF11-VISTA signaling. Targeting this communication pathway leads to tumor control by microglia and a favorable disease outcome. This positions IGS11-VISTA as a promising brain-specific therapeutic axis for DMG treatment.
Collot et al. profile tumor and immune interactions in DMG. They identify DMG tumor cells that communicate with microglia through IGSF11-VISTA signaling. Targeting this communication pathway leads to tumor control by microglia and a favorable disease outcome. This positions IGS11-VISTA as a promising brain-specific therapeutic axis for DMG treatment.