Haist et al. demonstrate that lymph node (LN) colonization induces systems-wide LN remodeling in patients with head-and-neck cancer using multiplex imaging, spatial transcriptomics, and a melanoma model of LN metastasis. The authors identify spatially organized immunomodulatory myeloid/CAF niches as key features of metastatic tolerance that associate with T cell dysfunction and Treg activation beyond the tumor-colonized LN.
Haist et al. demonstrate that lymph node (LN) colonization induces systems-wide LN remodeling in patients with head-and-neck cancer using multiplex imaging, spatial transcriptomics, and a melanoma model of LN metastasis. The authors identify spatially organized immunomodulatory myeloid/CAF niches as key features of metastatic tolerance that associate with T cell dysfunction and Treg activation beyond the tumor-colonized LN.