Tumor-associated macrophages sit at the crossroads of immune suppression and tumor destruction, prompting renewed interest in how their biology can be therapeutically redirected. Sun et al. synthesize recent advances in macrophage heterogeneity, engineering, and targeted reprogramming to highlight next-generation strategies that could turn macrophages into a powerful and versatile arm of cancer immunotherapy.
Tumor-associated macrophages sit at the crossroads of immune suppression and tumor destruction, prompting renewed interest in how their biology can be therapeutically redirected. Sun et al. synthesize recent advances in macrophage heterogeneity, engineering, and targeted reprogramming to highlight next-generation strategies that could turn macrophages into a powerful and versatile arm of cancer immunotherapy.