PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC

Official title: An Open-Label, Randomized Controlled Phase II Clinical Trial of PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent Nasopharyngeal Carcinoma

Summary: This phase II randomized trial evaluates PD-1 inhibitor plus chemotherapy followed by immediate versus selective re-irradiation in locally advanced recurrent nasopharyngeal carcinoma. The study aims to determine whether sequential radiotherapy provides additional survival benefit beyond systemic immunochemotherapy.

Conditions: Nasopharangeal Cancer, Recurrent Nasopharynx Carcinoma

Keywords: Locally Advanced Recurrent Nasopharyngeal Carcinoma

Study type: INTERVENTIONAL

Primary purpose: TREATMENT

Phases: PHASE2

Enrollment: 94 (ESTIMATED)

Status: RECRUITING

Completion: 2035-02-03 (ESTIMATED)