RECRUITING · INTERVENTIONAL · TREATMENT study · Rectal Adenocarcinoma · Phase 2 · Enrollment 200 · Sponsor: Memorial Sloan Kettering Cancer Center
Official title: A Phase II Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
Summary: The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced dMMR solid tumors. The study will also look at the safety of the study drug.
Conditions: Rectal Adenocarcinoma, Clinical Stage: Stage II (T3-4, N-), Stage III (Any T, N+), Solid Tumor, Solid Tumor, Adult
Keywords: PD1 blockade, TSR-042, Radiation, Capecitabine, 5-FU, 19-288, Solid tumor, Dostarlimab
Study type: INTERVENTIONAL
Primary purpose: TREATMENT
Phases: PHASE2
Enrollment: 200 (ESTIMATED)
Status: RECRUITING
Completion: 2026-11-30 (ESTIMATED)