Post-stroke acute heart failure in patients with large vessel occlusion undergoing endovascular treatment: A pooled analysis of individual patient data from multicenter studies with mediation analysis

07 Jul 20265 min read0 viewsJournal Feed

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by Liyuan Chen, Jiaxing Song, Changwei Guo, Linyu Li, Tao Xu, Chen Gong, Liping Huang, Shuyu Jiang, Lin Gao, Xinyu Li, Gang Wu, Xue Wang, Thanh N. Nguyen, Jeffrey L.
Saver, Yangmei Chen, Wenjie Zi, Chang Liu Background Cardiac complications rank among the leading contributors to poor outcomes in ischemic stroke patients along with the neurological impairment, while the risk stratification and prognostic significance of post-stroke acute heart failure (PSHF) remain poorly characterized. This study aimed to investigate the incidence, predictors, and impacts of PSHF in patients with large vessel occlusion stroke (LVO) undergoing endovascular treatment (EVT).
Given that cardioembolic stroke inherently involves underlying cardiac pathology, a secondary aim was to test whether the effect of stroke severity on PSHF was modified by cardioembolic etiology and whether PSHF mediated the effect of stroke severity on functional outcome in these patients. Methods and findings In a pooled analysis of individual patient data from four multicenter prospective studies conducted in China between January 2014 and June 2023, we included 3,415 patients with LVO who underwent EVT.

Clinical Editorial

PLOS Medicine published a clinical update in Research Highlights on 07 Jul 2026.

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