by Pyry N. Sipilä, Kaarina Korhonen, Joni V.
Lindbohm, Mika Kivimäki, Pekka Martikainen Background Severe infections have been linked to an increased risk of dementia, but both conditions often coexist with other illnesses that may confound this association. Using nationwide Finnish health registry data, we examined the role of noninfectious mental and physical illnesses in the association between severe infections and dementia.
Methods and findings This register-based study included 62,555 individuals aged 65 or older in Finland in 2016 who were diagnosed with late-onset dementia between 2017 and 2020 and 312,772 dementia-free controls matched for year of birth, sex, and the follow-up period. Analyses were adjusted for education, marital status, employment, and area of residence, with age and sex accounted for through the matched conditional design and analysis.
PLOS Medicine published a clinical update in Research Highlights on 24 Mar 2026.
The item focuses on The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study.
Review the original article for the full source wording and details.