Gene-Environment Equivalence: The Fundamental Principle Of Mendelian Randomization

by George Davey Smith, Gibran Hemani, Shah Ebrahim The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR. In this Perspective, George Davey Smith and colleagues outline how and why gene-environment equivalence, the fundamental principle of Mendelian Randomization (MR), must be properly applied and critically considered in MR studies.