An umbrella review navigating the nationwide burden of hepatitis B virus infection in Ethiopia: A call for action on vaccination, safe blood, and infection prevention

by Abel Desalegn Demeke, Aboma Tsegaye, Alem Bayable, Takla Tamir, Biazin Yenealem Mekuriaw, Behailu Taye Gebremeskele, Ababo Demeke, Mesfin Abebe, Abraham Dessie Gessesse, Delelegn Emwodew Yehualashet, Habtamu Gebrie, Endris Seid Amede Background The Hepatitis B virus (HBV) is one of the major causes of viral hepatitis that may persist and lead to complications, including cirrhosis, hepatic decompensation, and liver cancer. Numerous systematic reviews and meta-analysis have been conducted on HBV infection among people in Ethiopia, showing inconsistent findings.

This umbrella review aimed to assess the pooled prevalence of HBV infection and its associated factors among people in Ethiopia. Methods All published and unpublished systematic review and meta-analysis studies were searched on databases such as PubMed, Scopus, HINARI and Google Scholar.

A measurement tool to assess systematic reviews was used for critical appraisal of the included studies. STATA software version 17 was used to conduct the analysis.

I 2 test were used to determine heterogeneity, whereas funnel plots and Egger’s regression tests were used to assess publication bias.