by Ayesha Bibi, Muhammad Hamza Afandi, Azra Mehmood, Usman Ali Ashfaq, Muhammad Shareef Masoud, Mohsin Ahmad Khan, Rashid Bhatti Hepatocellular carcinoma (HCC) has a very significant mortality rate and is one of the most common cancers worldwide. Jacaranda mimosifolia is reported to have potential antitumor activities against various human cancers.
However, the effects of J. mimosifolia on HCC are yet elusive.
This study aimed to investigate the anti-HCC potential of methanolic extract of J. mimosifolia leaves using in vitro and in vivo studies and a network pharmacology approach.
The effect of J. mimosifolia extract was assessed on Huh-7.5 cells using MTT assay, wound healing assay, and DNA fragmentation assay.
These experiments found that J. mimosifolia extract significantly suppressed Huh-7.5 cell proliferation, impaired cell migration, and induced cell apoptosis.
The real-time PCR validated the upregulation of p53 and Bax , alongside the downregulation of AFP and GPC3 in Huh-7.5 cells after treatment with J. mimosifolia extract.
In vivo experiments confirmed the hepatoprotective effects of J. mimosifolia extract in mice models with CCl 4 -induced hepatic injury.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 03 Apr 2026.
The item focuses on Anti-hepatocellular carcinoma activity of Jacaranda mimosifolia through experimental validation and network pharmacology.
Review the original article for the full source wording and details.