by Jean A. Hall, Leslie B.
Hancock, Elizabeth M. Morris The aim of the study was to compare two renal foods with different Ca:P ratios on manifestation of hypercalcemia and regulation of calcium homeostasis in cats with chronic kidney disease (CKD).
Nine cats (11.0 ± 2.0 y) with naturally-occurring IRIS Stage I or II CKD were fed a senior wellness food for 28-days, then randomized into two groups and fed either a food providing 1.8 g/Mcal Ca, 1.3 g/Mcal P, and Ca:P ratio of 1.4:1 (MOD-Ca:P), or a food providing 2.4 g/Mcal Ca, 1.3 g/Mcal P, and Ca:P ratio of 1.8:1 (HIGH-Ca:P) for 56 days. After a 28-day washout period, cats were crossed over to the other test food.
Blood and urine samples were collected at the end of the prefeed/washout and on days 28 and 56 of each study period. Data were analyzed using a linear mixed model with fixed effects of Diet, Day, Period and associated interactions.
At baseline, mean ionized calcium (iCa; 1.26 ± 0.03 mmol/L) was within the normal reference interval (1.10–1.40 mmol/L).
PLOS ONE (Medicine) published a clinical update in Research Highlights on 29 May 2026.
The item focuses on Effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease.
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