by Mingming Pan, Yanhua Shen, Jiayu Wu, Chaonan Liu, Meihong Zhu, Zhengyu Zhou This study aimed to investigate the therapeutic effects of ELASEM ® Flex and ELASEM ® ProFlex, two eggshell membrane (EM) products, on sodium iodoacetate (MIA)-induced osteoarthritis (OA) in rats. An OA model was established by a single intra-articular injection of MIA into the knee joint.
After modeling, rats were administered diclofenac sodium, ELASEM ® Flex, and ELASEM ® ProFlex by gavage daily for 4 consecutive weeks. During the experiment, food intake, water intake, body weight, and plantar mechanical pain threshold (MPT) of rats were measured weekly.
Serum levels of TNF-α, COX-2, IL-1β, and CTX-II were assessed at weeks 2 and 4. After 4 weeks, knee joints were harvested for histopathological examination (HE staining and Safranin-O fast green staining).
Results indicated that knee joints of OA rats showed significant swelling, which was alleviated to varying degrees in all treatment groups.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 03 Apr 2026.
The item focuses on Study on the therapeutic effect of eggshell membrane on osteoarthritis in rats.
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