by Huan Lei, Biyue Wei, Xiao Dong, Meiling Jia, Xiaoyu Huang, Jingshu Yan, Furong Li, Meihua Liang Hyperuricemia (HUA) is an independent risk factor for cardiovascular disease (CVD), and low serum vitamin D levels are associated with an increased risk of CVD. However, their combined effect in patients with HUA has not been well characterized.
This study aimed to investigate the association between circulating vitamin D levels and CVD in patients with HUA, examine whether vitamin D deficiency (VDD) is associated with increased CVD prevalence, and determine the correlation between low vitamin D levels and CVD severity. The study employed a cross-sectional design and included clinical data of 483 patients with HUA admitted to the Second Affiliated Hospital of Harbin Medical University between 01/09/2023 and 01/11/2024.
According to the criteria by the National Academy of Medical Sciences, participants were stratified into three groups based on serum 25-hydroxyvitamin D (25(OH)D) concentrations: VDD group ( p p p = 0.004), total cholesterol (r = −0.181, p p p = 0.002).
PLOS ONE (Medicine) published a clinical update in Research Highlights on 03 Apr 2026.
The item focuses on Association between serum vitamin D levels and cardiovascular disease risk in patients with hyperuricemia: A cross-sectional study.
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