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Acinetobacter baumannii utilizes a novel protective factor to combat desiccation-induced oxidative stress
03 Jun 20264 min read0 viewsJournal Feed
GIST (Key Takeaways)
- by John M. Farrow III, Greg Wells, Everett C.
- Pesci One of the factors that facilitates the nosocomial spread of the frequently multidrug-resistant pathogen Acinetobacter baumannii is its ability to persist on dry surfaces for weeks. These bacteria do not form spores, but instead rely on a group of protective factors to survive desiccation.
- We investigated a protective factor of unknown function, referred to here as desiccation tolerance protein C (DtpC), which we found to be co-transcribed with another protective factor, the KatE catalase. A Δ dtpC Δ katE mutant strain had a greatly decreased ability to survive desiccation, but complementation with either dtpC or katE individually could restore survival to the wild-type level, showing that DtpC and KatE are each sufficient for desiccation tolerance.
- Since KatE also protects cells from oxidative stress, we examined whether oxygen had an effect on desiccation survival, and analyzed the formation of reactive oxygen species in dried cells.
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Summary
PLOS ONE (Medicine) published a clinical update in Research Highlights on 03 Jun 2026.
The item focuses on Acinetobacter baumannii utilizes a novel protective factor to combat desiccation-induced oxidative stress.
Review the original article for the full source wording and details.
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Feed Metadata
Source
PLOS ONE (Medicine)
Category
Research Highlights
Published
03 Jun 2026
Feed Metadata
Source
PLOS ONE (Medicine)
Category
Research Highlights
Published
03 Jun 2026