by Shaoli Huang, Xiaoyan Wang, Hongwu Xin, Xihe Zhang, Wenying Luo Background Venous thromboembolism (VTE) is a globally prevalent severe disease associated with high morbidity and mortality. Currently, thrombomodulin (TM), fibrinogen degradation product (FDP), thromboelastography have been the subject of several research pertaining to VTE; However, the combined diagnostic efficacy of these tests for VTE remains unclear.
Therefore, we proposed to investigate the diagnostic efficacy of TM, FDP, thrombelastography in predicting VTE. Methods The patients with traumatic fracture included in the study were divided into a VTE group (n = 44) and a control group (n = 56) based on imaging diagnosis.
Spearman correlation was employed to analyze the relationship between coagulation-related markers and thromboelastography indices. Variables were analyzed using multifactorial logistic stepwise regression.
Statistically significant indicators were included in the receiver operating characteristic curve to evaluate their diagnostic efficacy for VTE. Results The VTE group showed significantly higher levels of multiple coagulation-related parameters and thromboelastography indices compared to the control group.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 23 Apr 2026.
The item focuses on Risk prediction of combined fibrinogen degradation products, thrombomodulin, and maximum amplitude for assessing association with venous thromboembolism in patients with post-traumatic fractures.
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