Proceedings of the National Academy of Sciences, Volume 123, Issue 17, April 2026. SignificanceUFMylation is a ubiquitin-like modification mediated by a three-step enzymatic cascade that regulates protein homeostasis; however, its contribution to chromosomal instability (CIN)—a mitosis-associated hallmark that drives prostate cancer (...
PNAS published a clinical update in Research Highlights on 20 Apr 2026. The item focuses on Loss of UFL1 drives chromosome instability and tumorigenesis of prostate cancer. Open the detail page to review the full original feed content.