Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceInfluenza remains a major global health threat.
We introduce oseltamivir-based aziridines that unite transition-state mimicry for tight binding with aziridine-enabled covalent capture of the catalytic tyrosine. This dual function yields potent,...
PNAS published a clinical update in Research Highlights on 23 Mar 2026.
The item focuses on Oseltamivir aziridines are potent influenza neuraminidase inhibitors and imaging agents.
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