Dynamic Translocation of Inside-Out Proteins to the Cell Surface Underlies Cellular Adaptation t

Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceThis study describes “Inside-Out” (I-O) proteins, a class of intracellular proteins that translocate to the cell surface under stress or disease conditions through a mechanism distinct from conventional secretion pathways. I-O proteins are ...