Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. SignificanceMisfolding of cystic fibrosis transmembrane conductance regulator (CFTR) underlies cystic fibrosis, and its complex, multidomain architecture makes it an ideal model for understanding how membrane proteins fold and how small molecules can ...
PNAS published a clinical update in Research Highlights on 31 Mar 2026.
The item focuses on Single-molecule dissection of CFTR folding defects and pharmacological rescue.
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