Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. SignificanceSpermiogenesis requires extensive nuclear remodeling, involving the sequential replacement of histones by transition proteins (TNPs) and protamines to ensure proper sperm maturation. Although the removal of histones and TNPs is critical, the ...
PNAS published a clinical update in Research Highlights on 31 Mar 2026.
The item focuses on ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice.
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