Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. SignificanceThis study is motivated by a previously understudied natural pharmacophore, the spirocyclic β-lactone (SβL). This structurally distinct, potentially electrophilic pharmacophore is found in the oxazolomycin family of natural products known to ...
PNAS published a clinical update in Research Highlights on 31 Mar 2026.
The item focuses on Spirocyclic β-lactone secondary metabolites modulate spliceosome function.
Review the original article for the full source wording and details.