Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceGastric cancer remains one of the leading causes of cancer mortality, with limited tools to predict which patients will benefit from neoadjuvant chemotherapy. Our study reveals that aberrant activation of the serine metabolism enzyme PHGDH, ...
PNAS published a clinical update in Research Highlights on 25 Mar 2026.
The item focuses on PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment.
Review the original article for the full source wording and details.