Background Existing computed tomography (CT) vascular pruning measures rely on volumes, such as the proportion of blood volume in vessels with cross-sectional area (CSA) ≤5 mm 2 or CSA ≤10 mm 2 /total blood vessel volume (BV5/TBV or BV10/TBV, respectively), but may underestimate vascular pruning due to blood redistribution to larger vessels in individuals with milder COPD. We aim to develop a novel CT vessel measure, the total vessel count (TVC), quantify small and combined small/intermediate vessel count percentages, and compare these measures with BV5/TBV and BV10/TBV in terms of associations with lung function and its decline. As a secondary aim, associations with exercise capacity and COPD symptoms will be investigated. Methods CanCOLD (Canadian Cohort Obstructive Lung Disease) participants underwent CT imaging. BV5/TBV and BV10/TBV were generated using vessel segmentation. TVC and small (CSA ≤5 mm 2 , VC ≤5 /TVC) and combined small/intermediate (CSA ≤10 mm 2 , VC ≤10 /TVC) vessel count percentages were calculated.
Background Existing computed tomography (CT) vascular pruning measures rely on volumes, such as the proportion of blood volume in vessels with cross-sectional area (CSA) ≤5 mm 2 or CSA ≤10 mm 2 /total blood vessel volume (BV5/TBV or BV10/TBV, respectively), but may underestimate vascular pruning due to blood redistribution to larger vessels in individuals with milder COPD. We aim to develop a novel CT vessel measure, the total vessel count (TVC), quantify small and combined small/intermediate vessel count percentages, and compare these measures with BV5/TBV and BV10/TBV in terms of associations with lung function and its decline. As a secondary aim, associations with exercise capacity and COPD symptoms will be investigated. Methods CanCOLD (Canadian Cohort Obstructive Lung Disease) participants underwent CT imaging. BV5/TBV and BV10/TBV were generated using vessel segmentation. TVC and small (CSA ≤5 mm 2 , VC ≤5 /TVC) and combined small/intermediate (CSA ≤10 mm 2 , VC ≤10 /TVC) vessel count percentages were calculated. Fully adjusted regression models assessed associations with forced expiratory volume in 1 s (FEV 1 ), FEV 1 /forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide ( D LCO ), accelerated FEV 1 decline over 3 years, peak oxygen uptake ( V O 2 peak ), 6-min walk distance (6MWD) and Medical Research Council (MRC) dyspnoea scale. Results 1254 CanCOLD participants were investigated. TVC, VC ≤5 /TVC and VC ≤10 /TVC were associated with FEV 1 /FVC (p D LCO (p 1 decline (p ≤10 /TVC was associated with V O 2 peak (p ≤5 /TVC and VC ≤10 /TVC were associated with MRC (p Conclusion Pulmonary vessel count percent, a measure of vasculature narrowing/loss, is associated with lung function and its decline, reduced exercise capacity, and increased symptoms in COPD.