STAT+: From Revolution Medicines, more strong data on KRAS drug and a glimpse of a ‘novel class’ beyond it

SAN DIEGO — Revolution Medicines is already cooking up the next iteration of RAS-inhibiting drugs. At the American Association of Cancer Research annual meeting here, the company is the talk of the town for the clinical trial success of daraxonrasib , its next-generation targeted therapy, in advanced pancreatic cancer.

And while the company presented more data on that drug Tuesday, showing promising first-line and combination data on daraxonrasib, scientists also showed in another session intriguing preclinical data on a completely new compound that may represent what comes after the current lineup. That drug, currently called RM-055, is what RevMed CEO Mark Goldsmith is calling an entirely “novel class of catalytic inhibitors.” These are targeted therapies that not only block the RAS signaling that drives cancer, but molecularly turn the cancer protein off.   Continue to STAT+ to read the full story...